Method for inhibiting intracellular viral replication

Details Method for inhibiting intracellular viral replication Method for inhibiting intracellular viral replication

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61K 31/00 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/46 (2006.01) A61K 31/47 (2006.01) A61K 31/472 (2006.01) A61K 31/485 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61K 31/515 (2006.01) A61K 31/52 (2006.01) A61K 31/525 (2006.01)

Patent

CA 2153146

There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an effective amount of a compound that inhibits cellular signaling through a specific phospholipid-based cellular signaling and signal amplification pathway. The invention further provides a method for preventing or delaying clinical symptoms of a group of viral diseases wherein the viral disease is mediated by host cell viral replication. The invention provides an advantage by attacking host cellular signaling mechanisms to prevent the development of drug resistance from rapidly mutating viruses.

L'invention concerne un procédé permettant de prévenir ou de retarder l'apparition du syndrome d'immunodéficience acquise (SIDA) chez les individus séropositifs, atteints par le virus de l'immunodéficience humaine (VIH), par administration d'une quantité efficace d'un composé qui inhibe la signalisation cellulaire qui s'effectue par un groupe spécifique de voies de signalisation cellulaire à base de phospholipides et d'amplification des signaux. L'invention concerne en outre un procédé permettant de prévenir ou de retarder l'apparition des symptômes cliniques d'un groupe d'affections virales dans lequel l'affection virale est transmise par réplication virale dans les cellules hôtes. L'invention se caractérise en ce qu'elle permet de lutter contre les mécanismes de signalisation des cellules hôtes afin d'empêcher des virus à mutation rapide de développer une résistance aux médicaments.

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