C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) C12N 5/12 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2350391
Methods to inhibit inflammation and macrophage infiltration following spinal cord injury are disclosed along with methods to modulate TNF-alpha release from cells expressing alpha-d. Anti-alpha-d monoclonal antibodies are used to block binding between alpha-d and VCAM-1. Hybridoma secreting the antibodies are disclosed, as well as diagnostic methods using the antibodies.
L'invention concerne des procédés relatifs à l'inhibition de l'inflammation et de l'infiltration des macrophages, suite à un traumatisme médullaire, ainsi que des procédés relatifs à la modulation de la libération du TNF alpha depuis les cellules qui expriment .alpha.¿d?. On utilise des anticorps monoclonaux anti-alpha-d pour bloquer les liaisons entre alpha-d et VCAM-1. L'invention concerne en outre un hybridome sécrétant les anticorps considérés et des procédés diagnostiques reposant sur l'utilisation de ces anticorps.
Gallatin Michael W.
Van Der Vieren Monica
Icos Corporation
Smart & Biggar
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