Method for inhibiting thrombosis in a patient whose blood is...

A - Human Necessities – 61 – K

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A61K 38/48 (2006.01) A61K 38/36 (2006.01) A61M 1/36 (2006.01) C12N 9/64 (2006.01) C12Q 1/56 (2006.01) G01N 33/86 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2326634

This invention is a method for inhibiting thrombosis in a patient whose blood is subjected to extra-corporeal blood circulation which comprises contacting the extra-corporeal circulating blood with a Factor IXa compound in an amount effective to inhibit thrombosis in the patient. The patient may be subjected to extra-corporeal blood circulation during transplant surgery or cardiopulmonary bypass surgery or any surgery in which obligate clamping of a blood vessel is required. Further, a pharmaceutical composition includes an effective amount of a Factor IXa compound, and a pharmaceutically acceptable carrier.

L'invention concerne une méthode destinée à inhiber la thrombose chez un patient dont le sang est soumis à une circulation extracorporelle, ladite méthode consistant à mettre le sang en circulation extracorporelle au contact d'un composé de Facteur IXa, présent en une quantité suffisante pour inhiber la thrombose chez le patient. Le patient peut être soumis à une circulation extracorporelle lors d'une transplantation, d'un pontage cardio-pulmonaire ou de toute intervention chirurgicale nécessitant le clampage d'un vaisseau sanguin. En outre, l'invention concerne une composition pharmaceutique comprenant une dose efficace d'un composé de Facteur IXa, ainsi qu'un excipient pharmaceutiquement acceptable.

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