Method for inhibition of necrosis induced by neurotrophin

Details Method for inhibition of necrosis induced by neurotrophin Method for inhibition of necrosis induced by neurotrophin

A - Human Necessities

61

K

A61K 31/60 (2006.01)

Patent

CA 2518888

Disclosed is a method for inhibition of necrosis induced by neurotrophin, and more specifically a method for inhibition of necrosis by administrating oxidative stress inhibitor and a method for simultaneous inhibition of necrosis and apoptosis by administrating oxidative stress inhibitor and neurotrophin. The oxidative stress inhibitor of the present invention can inhibit nerve cell necrosis induced by neurotrophin. Moreover, it can be used for protecting nerve cell damage connected with alzheimer disease, parkinson~s disease, degenerating cerebropathia and promoting regeneration of the nerve cells by administrating oxidative stress inhibitor and neurotrophin.

L'invention concerne une méthode d'inhibition de nécrose induite par la neurotrophine et plus spécifiquement une méthode d'inhibition de nécrose par administration d'un inhibiteur de stress oxydatif ainsi qu'une méthode d'inhibition simultanée de nécrose et d'apoptose par administration d'un inhibiteur de stress oxydatif et de neurotrophine. L'inhibiteur de stress oxydatif selon la présente invention peut inhiber la nécrose neuronale induite par la neurotrophine. De plus, il peut être utilisé pour protéger contre la détérioration neuronale liée à la maladie d'Alzheimer, à la maladie de Parkinson, à la cérébropathie dégénérative et favoriser la régénération neuronale par administration d'un inhibiteur de stress oxydatif et de neurotrophine.

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