Method for introducing a pna molecule conjugated to a...

Details Method for introducing a pna molecule conjugated to a... Method for introducing a pna molecule conjugated to a...

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 41/00 (2006.01)

Patent

CA 2571696

The present application relates to a method for introducing a PNA molecule into the cytosol, preferably the nucleus of a cell, comprising contacting said cell with a PNA molecule and a photosensitising agent, and irradiating the cell with light of a wavelength effective to activate the photosensitising agent, wherein said PNA molecule is conjugated to a positively charged peptide. Compositions comprising such conjugated PNA molecules, cells made using the method and uses of the method are also described.

L'invention concerne un procédé d'introduction d'une molécule de PNA dans le cytosol, de préférence dans le noyau, d'une cellule. Ce procédé consiste à mettre ladite cellule en contact avec une molécule de PNA et un agent photosensibilisateur, et à irradier la cellule au moyen d'une lumière présentant une longueur d'onde efficace pour activer l'agent photosensibilisateur, la molécule de PNA étant conjuguée à un peptide à charge positive. L'invention concerne également des compositions contenant ces molécules de PNA conjuguées, des cellules obtenues par la mise en oeuvre de ce procédé, ainsi que les utilisations dudit procédé.

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