Method for introducing and expressing rna in animal cells

Details Method for introducing and expressing rna in animal cells Method for introducing and expressing rna in animal cells

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) C07K 14/24 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2305785

The invention pertains to a method for introducing RNA molecules into eukaryotic cells, wherein the RNA molecules are capable of being translated in the eukaryotic cells or is an antisense RNA or a catalytic RNA, as well as to such bacteria, compositions comprising such bacteria, and nucleic acids which can be introduced into bacteria for practicing the method of the invention. Examples of products the RNA molecule may encode include vaccine antigens, therapeutic agents, immunoregulatory agents or anti-sense RNA molecules or catalytic RNA molecules.

L'invention concerne un procédé permettant d'introduire des molécules d'ARN dans des cellules eucaryotiques, ces molécules d'ARN pouvant être traduites dans les cellules eucariyotiques ou étant composées d'ARN antisens ou d'ARN catalytique. L'invention concerne également des compositions bactériennes comprenant des bactéries et des acides nucléiques qui peuvent être introduits dans ces bactéries en application de ce procédé. Les produits pouvant être codés par cette molécules d'ARN sont par exemple des antigènes de vaccin, des agents thérapeutiques, des agent immunorégulateurs ou des molécules d'ARN antisens ou d'ARN catalytique.

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