Method for introducing pharmaceutical drugs and nucleic...

Details Method for introducing pharmaceutical drugs and nucleic... Method for introducing pharmaceutical drugs and nucleic...

A - Human Necessities

61

N

A61N 1/18 (2006.01) A61N 1/32 (2006.01) A61N 5/00 (2006.01) A61N 1/36 (2006.01)

Patent

CA 2285056

A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The pharmaceutical drug or nucleic acid is first injected into the muscle at one or multiple sites. Immediately, or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the pharmaceutical drug or nucleic acid to enter the cell. The efficiency of transfer permits robust immune responses using DNA vaccines and produces sufficient secreted proteins for systemic biological activity to be observed. The use of a drug for manufacturing a medicament to be used in the delivery method as well as a device for performing the method and the use of such a device is also disclosed.

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