Method for isolating hepatitis c virus peptides

Details Method for isolating hepatitis c virus peptides Method for isolating hepatitis c virus peptides

A - Human Necessities

61

K

A61K 39/00 (2006.01)

Patent

CA 2484339

Described is a method for isolating Hepatitis C Virus peptides (HPs) which have a binding capacity to a MHC/HLA molecule or a complex comprising said HCV- peptide and said MHC/HLA molecule characterized by the following steps: - providing a pool of HCV-peptide, said pool containing HCV-peptides which bind to said MHC/HLA molecule and HCV-peptides which do not bind to said MHC/HLA molecule, -contacting said MHC/HLA molecule with said pool of HCV-peptides whereby a HCV-peptide which has a binding capacity to said MHC/HLA molecule binds to said MHC/HLA molecule and a complex comprising said HCV-peptide and said MHC/HLA molecule is formed, -detecting and optionally separating said complex from the HCV-peptide which do not bind to said MHC/HLA molecule and optionally isolating and characterising the HCV-peptide from said complex.

La présente invention concerne un procédé pour isoler des peptides du virus de l'hépatite C (HPs) qui ont une capacité de liaison à une molécule CMH/HLA ou un complexe comprenant ledit peptide du virus de l'hépatite C (VHC) et ladite molécule CMH/HLA. Le procédé se caractérise en ce qu'il comprend les étapes suivantes: mise à disposition d'un ensemble de peptides de VHC, ledit ensemble contenant des peptides de VHC qui se lient à ladite molécule CMH/HLA et des peptides de VHC qui ne se lient pas à ladite molécule CMH/HLA; mise en contact de ladite molécule CMH/HLA avec ledit ensemble de peptides de VHC, un peptide de VHC qui a une capacité de liaison à ladite molécule CMH/HLA se liant alors à ladite molécule CMH/HLA et un complexe comprenant ledit peptide de VHC et la molécule CMH/HLA étant formé; détection et éventuellement séparation dudit complexe du peptide de VHC qui ne se lie pas à ladite molécule de CMH/HLA et éventuellement isolation et caractérisation du peptide de VHC dudit complexe.

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