C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2506890
A method is described for isolating neutralizing intracellular antibodies of an interaction between a protein ligand x and a protein ligand y inside a cell. A method to identify a protein ligand x able to bind to a known y ligand using intracellular antibodies able to disrupt the interaction between x and y is also described. A method for the isolation of a set of antibody fragments against a significant proportion of the protein-protein interactions of a given cell (interactome) or against the protein interactions that constitute an intracellular pathway or network is also described.
L'invention concerne une méthode d'isolement d'anticorps intracellulaires de neutralisation d'une interaction entre un ligand protéique x et un ligand protéique y à l'intérieur d'une cellule. L'invention concerne également une méthode d'identification d'un ligand protéique x de liaison à un ligand y connu à l'aide d'anticorps intracellulaires pouvant interrompre l'interaction entre x et y. L'invention concerne en outre une méthode d'isolement d'un ensemble de fragments d'anticorps face à une proportion significative d'interactions protéine-protéine d'une cellule donnée (interactome) ou aux interactions protéiques constituant une voie ou réseau intracellulaire.
Cattaneo Antonino
Visintin Michela
Dennison Associates
Lay Line Genomics S.p.a.
Rottapharm Biotech S.r.l.
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