Method for labeling phosphorylated peptides, method for...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/36 (2006.01) C07F 3/06 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2517705

Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods. The complex compound is represented by the formula: (see formula I) wherein X is a linker moiety, and Y is a labeling group. The compound (I) is highly coordinated to a phosphorylated peptide, and has a labeling group. Accordingly, with use of the compound (I), the phosphorylated peptide can be easily identified.

L'invention concerne un procédé de détection facile de peptides phosphorylés (protéines) dans un échantillon biologique, etc. ; un procédé d'adsorption sélective afférent ; et un composé présentant une haute capacité de liaison de coordination avec des peptides phosphorylés pour permettre ainsi une utilisation dans les procédés. Le composé est représenté par la formule (I) dans laquelle X représente un groupe de liaison et Y un groupe de marquage. Le composé (I) présente une haute capacité de liaison de coordination avec des peptides phosphorylés et il présente un groupe de marquage, de telle sorte que les peptides phosphorylés peuvent être identifiés facilement par son utilisation.

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