Method for ligating oligopeptides

Details Method for ligating oligopeptides Method for ligating oligopeptides

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) C07K 1/00 (2006.01) C07K 1/02 (2006.01) C07K 1/04 (2006.01) C07K 1/10 (2006.01) C07K 1/107 (2006.01)

Patent

CA 2273071

Oligopeptides are ligated to form ligation peptide products. In the first step, two starting oligopeptides are ligated to form an intermediate having an aminothioester linkage. In the second step, the aminothioester linkage undergoes a rearrangement to form a peptide having an N-substituted amide linkage. In an optional third step, the N- substitution of the amide linkage is chemically removed to form a native peptide linkage.

Des oligopeptides sont ligaturés pour former des produits peptidiques ligaturés. Dans la première étape, deux oligopeptides de départ sont ligaturés pour former un intermédiaire ayant une liaison aminothioester. Dans la deuxième étape, la liaison aminothioester est soumise à un réagencement pour former un peptide ayant une liaison amide à substitution N. Dans une troisième étape éventuelle, la substitution N de la liaison amide est chimiquement supprimée pour former une liaison peptidique naturelle.

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