Method for loading a red blood cell with an agent

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/50 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) C12N 3/00 (2006.01)

Patent

CA 2398296

We describe a method of producing a red blood cell suitable for delivery of an agent to a vertebrate, the method comprising: (a) providing a red blood cell; (b) pre-sensitising the red blood cell; and (c) loading the red blood cell with an agent. Use of an electric field and/or ultrasound to increase the efficiency of loading of an agent into a red blood cell is also described.

L'invention concerne un procédé de production d'un globule rouge convenant à l'administration d'un agent à un vertébré, ce procédé consistant : (a) à prendre un globule rouge ; (b) à présensibiliser ce globule rouge ; et (c) à charger le globule rouge avec un agent. L'invention concerne également l'utilisation d'un champ électrique et/ou d'ultrasons en vue d'accroître l'efficacité du chargement d'un agent dans un globule rouge.

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