Method for localized administration of fibrinolytic...

Details Method for localized administration of fibrinolytic... Method for localized administration of fibrinolytic...

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2394613

A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of .alpha.2-macroglobulin in the circulating blood.

L'invention concerne une méthode d'administration intravasculaire localisée d'une métalloprotéase fibrinolytique à un sujet humain, dans des quantités propres à lyser de manière sûre et effective un caillot sanguin d'occlusion contenant de la fibrine, tout en évitant l'effet de neutralisation de la macroglobuline alpha-2 dans le sang circulant.

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