C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2336220
The TGF-.beta. family of growth factors, particularly the bone morphogenetic protein (BMP)-2/4 homolog decapentaplegic (dpp), are specifically required to maintain germline stem cells and promote their division. Overexpression of dpp blocks germline stem cell differentiation. Mutations in dpp or its receptor saxophone accelerate stem cell loss and retard stem cell division. dpp signaling is directly received by germline stem cells, and thus dpp signaling helps define a niche that controls germline stem cell proliferation.
La famille TGF-.beta. des facteurs de croissance, notamment la décapentaplégique (dpp) homologue de la protéine morphogénétique osseuse (BMP)-2/4, est particulièrement indispensable pour préserver des cellules souches de germen et favoriser leur division. Une surexpression de la dpp bloque la différenciation de la cellule souche de germen. Des mutations se produisant dans la dpp ou dans son récepteur saxophone, accélèrent la perte de la cellule souche et retardent sa division. Une signalisation de la dpp est directement reçue par les cellules souches de germen et cette signalisation contribue à la définition d'une niche agissant sur la prolifération de la cellule souche de germen.
Spradling Allan C.
Xie Ting
Gowan Intellectual Property
The Carnegie Institution Of Washington
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