Method for making...

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C - Chemistry, Metallurgy

07

D

C07D 215/42 (2006.01)

Patent

CA 2327029

Cholesterol ester transfer protein (CETP) inhibitors, as well as methods for making such inhibitors are disclosed. These inhibitors include 4-(3,5-bis-trifluoromethylbenzyl- amino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline- 1-carboxyl acid ethyl ester, 4-toluene-sulfonate; (-)-(2R,4S)- 4-(3,5-bis-trifluoromethylbenzylamino)-2-ethyl-6-trifluoro- methyl-3,4-dihydro-2H-quinoline-1-carboxyl acid ethyl ester or pharmaceutically acceptable salts thereof, preferably the 4-toluene-sulfonate salt thereof; cis-4-amino-2-ethyl-6- trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester and pharmaceutically acceptable salts thereof, preferably the (-)di-benzoyl-L-tartrate salt or (-)di-p- toluoyl-L-tartaric acid salt thereof; and (-)(2R,4S)-4-amino-2- ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester and pharmaceutically acceptable salts thereof, preferably the (-)di-benzoyl-L-tartrate salt or (-)di-p- toluoyl-L-tartaric acid salt thereof.

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