Method for making acylated polypeptides

Details Method for making acylated polypeptides Method for making acylated polypeptides

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) C07K 1/107 (2006.01) C07K 14/605 (2006.01)

Patent

CA 2452735

The present invention is related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the claimed method. Further, the present invention is related to certain precursors of the desired polypeptides and certain acylation methods. The invention provides a method for making polypeptides being preferentially acylated in certain lysine .epsilon.-amino groups.

La présente invention concerne un procédé de production de polypeptides dans des cellules hôtes transformées par expression d'une molécule précurseur du polypeptide souhaité. Ces polypeptides sont acylés dans une étape in vito consécutive. L'invention concerne également des séquences ADN, des vecteurs et des cellules hôtes transformées destinés à être utilisés dans le procédé selon l'invention. En outre, la présente invention concerne certains précurseurs des polypeptides souhaités et certains procédés d'acylation. L'invention concerne enfin un procédé permettant de produire des polypeptides qui, de préférence, sont acylés dans des certains groupes lysine .epsilon.-amino.

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