C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/00 (2006.01) C07D 211/70 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2489375
A method for making an indole compound includes transition metal-catalyzed arylation of a hydrazone, hydrolysis of the aryl hydrazone to form an aryl hydrazine, and acid catalyzed cyclization of the aryl hydrazine to form the indole compound.
L'invention concerne un procédé d'élaboration d'un composé d'indole comprenant l'arylation catalysée par un métal de transition d'un hydrazone pour former un hydrazone d'aryle, l'hydrolyse de l'hydrazone d'aryle, afin de former un hydrazine d'aryle, et la cyclisation catalysée acide de l'hydrazine d'aryle pour constituer le composé d'indole.
Bennetti Richard E.
Gou Da-Ming
Hicks Frederick
Marchese Salvatore Anthony
Martel Lawrence J.
Gowling Lafleur Henderson Llp
Rhodia Pharma Solutions Inc.
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