A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2375600
The invention concerns a method for making coated granules with masked taste and instant release of the active principle which consists in: first, mixing the constituents of a powder comprising at least the active principle and a granular disintegrating agent; then, granulating the resulting powder, in the presence of a mixture of carriers comprising at least a binding agent capable of binding the particles together to obtain grains; coating the grains formed by spraying a suspension comprising at least a coating agent and a membrane disintegrating agent; finally drying the resulting coated granules.
Procédé de fabrication de granules enrobés à goût masqué, et libération immédiate du principe actif selon lequel: tout d'abord, on mélange à sec les constituants d'une poudre comprenant au moins le principe actif et un agent désintégrant granulaire; on granule ensuite la poudre obtenue, en présence d'un mélange d'excipients comprenant au moins un agent liant apte à lier les particules entre elles pour obtenir des grains; on enrobe alors les grains formés par pulvérisation d'une suspension comprenant au moins un agent d'enrobage et un agent désintégrant membranaire; enfin, on sèche les granules enrobés obtenus.
Bruna Etienne
Chauveau Charles
Nouri Noureddine
Zuccarelli Jean-Marc
Brouillette & Associes/partners
Ethypharm
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