Method for making heteromultimeric molecules

Details Method for making heteromultimeric molecules Method for making heteromultimeric molecules

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 16/00 (2006.01) C07K 16/22 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2759233

The present invention provides methods for making heteromultimeric molecules, such as bispecif?c antibodies, and compositions comprising said molecules. The method includes introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.

La présente invention porte sur des procédés de fabrication de molécules hétéromultimères telles que des anticorps biospécifiques et sur des compositions comprenant lesdites molécules. Le procédé comprend l'introduction de mutations dans des acides aminés qui sont en contact à l'interface de deux polypeptides, de telle sorte que l'interaction électrostatique entre les paires ioniques est altérée.

Affiliated with

Also associated with

Rating

Method for making heteromultimeric molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for making heteromultimeric molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for making heteromultimeric molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1610579