Method for making homogeneous spray-dried solid amorphous...

Details Method for making homogeneous spray-dried solid amorphous... Method for making homogeneous spray-dried solid amorphous...

A - Human Necessities

61

K

A61K 9/16 (2006.01)

Patent

CA 2474958

Homogeneous solid amorphous dispersions of drugs in concentration-enhancing polymers are formed in desirable larger particle sizes with minimal fines by using an atomizer and process conditions capable of producing droplets having an average diameter of at least 50 microns and a D10 of at least 10 microns.

Selon l'invention, pour former des dispersions médicamenteuses amorphes solides homogènes dans des polymères renforçant la concentration, avec des tailles de particules supérieures et une production minimale de fines, on utilise un atomiseur et des conditions de traitement qui permettent de produire des gouttelettes présentant un diamètre moyen d'au moins 50 microns et un D¿10? d'au moins 10 microns.

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