Method for making insulin precursors and insulin precursor...

Details Method for making insulin precursors and insulin precursor... Method for making insulin precursors and insulin precursor...

C - Chemistry, Metallurgy

12

P

C12P 21/02 (2006.01) C07K 14/62 (2006.01)

Patent

CA 2392844

Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 .ANG..

L'invention porte sur de nouveaux précurseurs de l'insuline et sur des analogues des précurseurs de l'insuline comprenant un peptide C (mini peptide C) contenant jusqu'à 15 restes d'acides aminés et comprenant au moins un Gly. Les précurseurs peuvent être convertis en insuline humaine ou en un analogue d'insuline humaine. Les précurseurs ont généralement une distance comprise entre B27 (atome CG2) et A1 (atome CA) de moins de 5 .ANG..

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