C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 303/36 (2006.01) C07C 213/00 (2006.01) C07C 213/02 (2006.01) C07C 213/08 (2006.01) C07C 215/28 (2006.01) C07C 221/00 (2006.01) C07C 223/02 (2006.01) C07C 269/06 (2006.01) C07C 271/10 (2006.01) C07C 275/22 (2006.01) C07C 275/24 (2006.01) C07C 317/44 (2006.01) C07D 215/48 (2006.01) C07D 295/088 (2006.01) C07D 295/108 (2006.01) C07D 301/02 (2006.01) C07D 405/06 (2006.01) C07F 7/10 (2006.01) C07K 5/02 (2006.01) C07C 271/16 (2006.01)
Patent
CA 2131182
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R1 is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR9 or SR9, where R9 represents hydrogen or alkyl; and P1 and P2 independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.
Getman Daniel P.
Mueller Richard A.
Ng John S.
Przybyla Claire A.
Vazquez Michael L.
G.d. Searle & Co.
G.d. Searle Llc
Monsanto Company
Sim & Mcburney
LandOfFree
Method for making intermediates useful in synthesis of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for making intermediates useful in synthesis of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for making intermediates useful in synthesis of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1555548