Method for making substituted indoles

Details Method for making substituted indoles Method for making substituted indoles

C - Chemistry, Metallurgy

07

D

C07D 209/12 (2006.01) C07D 209/16 (2006.01)

Patent

CA 2332766

Disclosed is a method of preparing a compound represented by structural formula (II), and physiological salts thereof. R1 is -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R2 is a substituted or unsubstituted 2-hydroxy-1-ethyl group. Ring A is a substituted or unsubstituted aryl group. Ring B is substituted or unsubstituted at position two. The method comprises reacting a substituted or unsubstituted aryl hydrazine or salt derived from a substituted or unsubstituted aryl hydrazine with a compound represented by structural formula (III).

La présente invention concerne un procédé permettant de préparer un composé représenté par la formule structurelle (II) et certains de ses sels physiologiques. R?1¿ est H, un groupe aliphatique, un groupe aliphatique substitué, un groupe aryle ou un groupe aryle substitué. R?2¿ est un groupe 2-hydroxy-1-éthyle. Le cycle A est un groupe aryle substitué ou non substitué. Le cycle N est substitué ou non substitué en position deux. Le procédé consiste à faire réagir avec un composé représenté par la formule structurelle (III) une arylhydrazine substituée ou non substituée ou un sel dérivé d'une arylhydrazine substituée ou non substituée.

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