Method for making universal donor cells

Details Method for making universal donor cells Method for making universal donor cells

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2126692

Transplantation antigen-depleted cells and methods for making such cells from a target cell are provided. The transplanta- tion antigen-depleted cell is made by exposing a target cell to an oligonucleotide capable of binding to a transplantation antigen nucleotide sequence. The oligonucleotide is capable of binding to the nucleotide sequence according to Watson-Crick or triplex binding rules. Preferred transplantation antigens are the MHC class I or II antigens. Oligonucleotides useful in practicing this method are also provided.

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