Method for making valproic acid derivatives

Details Method for making valproic acid derivatives Method for making valproic acid derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 39/385 (2006.01) C07C 51/09 (2006.01) C07C 51/347 (2006.01) C07C 51/353 (2006.01) C07C 51/38 (2006.01) C07C 55/02 (2006.01) C07C 69/34 (2006.01) C07C 227/12 (2006.01) C07C 229/08 (2006.01) G01N 33/531 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2122816

2122816 9406745 PCTABS00030 A method for making a valproic acid derivative comprising a functionalized spacer arm attached to a .delta. carbon atom of a valproic acid molecule is disclosed. The method proceeds by attaching a spacer arm joined to an inorganic moiety to a valproic acid precursor to make an alkylated compound, derivatizing the alkylated compound in a liquid medium to make the valproic acid derivative, and then separating the valproic acid derivative from the liquid medium. The valproic acid derivative can be used to make an immunoreactive valproic acid conjugate.

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