Method for manufacture of escitalopram

Details Method for manufacture of escitalopram Method for manufacture of escitalopram

C - Chemistry, Metallurgy

07

C

C07C 255/59 (2006.01) C07B 57/00 (2006.01) C07C 69/767 (2006.01) C07D 307/87 (2006.01)

Patent

CA 2638499

This patent discloses a method for resolution of 4-¬4-(dimethylamino)- 1-(4'-fluorophenyl)-1-hydroxybutyl|-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallising 4-¬4-(dimethylamino)-1-(4'- fluoro- phenyl)-1-hydroxybutyl|-3-(hydroxymethyl)-benzonitrile as a salt with the (+)- (S,S)- or (-)-(R,R)-enantiomer of O, O'-di-p-toluoyl-tartaric acid in a solvent system comprising 1-propanol, ethanol or acetonitrile.

Le présent brevet a pour objet une méthode pour la séparation de mélanges racémiques ou non racémiques de 4-¬4-(diméthylamino)-1-(4'-fluorophényl)-1-hydroxybutyl|-3-(hydroxyméthyl)benzonitrile en ses énantiomères. Ladite méthode comprend une étape de cristallisation fractionnée du 4-¬4-(diméthylamino)-1-(4'-fluorophényl)-1-hydroxybutyl|-3-(hydroxyméthyl)benzonitrile sous forme de sel avec les énantiomères (+)-(S,S)- ou (-)-(R,R) de l'acide O, O'-di-p-toluoyltartarique dans un solvant comprenant du propan-1-ol, de l'éthanol ou de l'acétonitrile.

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