Method for manufacture of sertindole

Details Method for manufacture of sertindole Method for manufacture of sertindole

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) C07D 209/08 (2006.01)

Patent

CA 2480239

The present invention relates to a novel method for manufacture of sertindole comprising manufacturing 5-chloro-1-(4-fluorophenyl)-indole and converting it to sertindole wherein the method for manufacture of 5-chloro-1-(4- fluorophenyl)-indole comprises reacting 5-chloro-indole with a 4- fluorophenylhalide in the presence of a base, a chelating ligand and catalytic amounts of a copper salt comprising copper(I) or copper(II) and an anion which does not interfere in an unfavourable way with the reaction.

Cette invention concerne un nouveau procédé de fabrication de sertindole consistant à fabriquer un 5-chloro-1-(4-fluorophényl)-indole et à le convertir en sertindole. Le procédé de fabrication de 5-chloro-1-(4-fluorophényl)-indole consiste à faire réagir un 5-chloro-indole avec un 4-fluorophénylhalogénure en présence d'une base, d'un ligand chélateur et de quantités catalytiques d'un sel de cuivre comprenant du cuivre(I) ou du cuivre(II) ainsi qu'un anion qui ne vient pas perturber la réaction.

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