Method for manufacturing (3s,4r)-4-¬(r)-1'-formylethyl|...

Details Method for manufacturing (3s,4r)-4-¬(r)-1'-formylethyl|... Method for manufacturing (3s,4r)-4-¬(r)-1'-formylethyl|...

C - Chemistry, Metallurgy

07

D

C07D 205/08 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2276543

A method for manufacturing (3S,4R)-4-[(R)-1'- formylethyl]azetidin-2-one derivatives represented by formula (3) wherein R1 represents a hydrogen atom or a protective group, through asymmetric hydroformylation of 4-vinylazetidin-2-one represented by formula (1) wherein R1 has the same meaning as described above; in the presence of a rhodium complex and a (2S,4S)-diphosphine compound represented by formula (2) wherein R2 represents a phenyl group which may be substituted with 1-5 substituent(s) selected from a lower alkyl group, a lower alkoxy group, and a halogen atom. (see above formula) By use of both an inexpensive optically active diphosphine compound and a rhodium complex as catalysts, intermediate compounds important for carbapenem antibiotics can be manufactured with high selectivity and efficiency.

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