C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01)
Patent
CA 2495823
A method for manufacturing hydrogen sulphate (alpha S) of the alpha-(2- chlorophenyl)-6,7~dihydro-thieno~3,2-c~pyridine-5(4H)-acetic acid methyl ester (clopidogrel hydrogen sulphate) of formula I, in crystalline Form I, wherein the compound of formula is separated out of a solution of clopidogrel in the form of the free base or salt in a solvent selected from the series of primary, secondary or tertiary C1-C5 alcohols, their esters with Cl-C4 carboxylic acids, or optionally of mixtures thereof.
L'invention concerne un procédé de fabrication du sulfate d'hydrogène (alpha S) de l'ester méthylique de l'acide alpha-(2-chlorophényl)-6,7-dihydro-thiénoÝ3,2-c¨pyridine-5(4H)-acétique (clopidogrel hydrogène sulfate) de formule (I), sous la forme cristalline I, dans lequel le composé de la formule est séparé d'une solution de clopidogrel sous la forme d'une base libre ou de sel dans un solvant sélectionné parmi la série des alcools primaire, secondaire, tertiaire en C1-C5, de leurs esters avec des acides carboxyliques en C1-C4, ou éventuellement des mélanges de ces produits.
Hajicek Josef
Stepankova Hana
Veverka Miroslav
Veverkova Eva
Vodny Stefan
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
Zentiva A.s.
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