C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/128.7
C12P 21/02 (2006.01) C07K 5/072 (2006.01)
Patent
CA 1133841
ABSTRACT OF THE DISCLOSURE: An improvement in a method for manufacturing dipeptides from an N-substituted aspartic acid and a phenylalanine lower alkyl ester. The two starting materials are allowed to react with each other in the presence of an immobilized metallo-proteinase in an organic solvent immiscible with water. The enzyme can be recovered for reuse thereof. The loss of materials due to the hydrolysis of the phenylalanine lower alkyl ester is reduced, so that use of the phenylalanine lower alkyl ester in a nearly stoichiometric quantity suffices for the reaction to ensure an improved yield and reduction in cost of industrial production.
348800
Hashimoto Tsutomu
Kihara Keiichi
Nishimura Shigeaki
Nonaka Yuji
Oyama Kiyotaka
Ajinomoto Co. Inc.
Borden Ladner Gervais Llp
Sagami Chemical Research Center
Toyo Soda Manufacturing Co. Ltd.
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