Method for mapping and eliminating t-cell epitopes

Details Method for mapping and eliminating t-cell epitopes Method for mapping and eliminating t-cell epitopes

G - Physics

01

N

G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2489180

The invention provides screening methods for the identification of determinants and epitopes on protein molecules able to evoke an immune response. In particular the invention is concerned with the identification of epitopes for T-cells in therapeutic proteins. Finally, the invention relates to a combined approach of using epitope mapping in concert with the identification of MHC class II ligands deriving from said epitope mapping method and design of sequence analogous having a reduced number of such ligands and epitopes, respectively.

L'invention concerne des méthodes de criblage destinées à l'identification de déterminants et d'épitopes sur des molécules protéiques capables d'induire une réponse immune. L'invention concerne plus particulièrement l'identification d'épitopes T dans des protéines thérapeutiques. Finalement, l'invention concerne une approche combinée faisant intervenir la cartographie des épitopes et l'identification de ligands de molécules du CMH de classe II dérivant de ladite méthode de cartographie des épitopes, ainsi que la conception de séquences analogues ayant un nombre réduit de ces ligands et épitopes, respectivement.

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