A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/48 (2006.01) C12Q 1/56 (2006.01) G01N 33/86 (2006.01)
Patent
CA 2378898
The present invention is directed to methods to rapidly assess the overall coagulant properties of a patient's blood sample by measuring and comparing clotting time with and without an added inhibitor of a procoagulant or an anticoagulant. When the sample is whole blood, the resulting clotting time represents the overall coagulant activity of the plasma and cellular components of the blood, which is indicative of existing or impending pathology arising from abnormal coagulability. The invention also provides a method for measuring the risk of a patient for a thrombotic event by determining functionally current levels of one or more procoagulants or anticoagulants in whole blood. In addition, a method for measuring the effectiveness of anticoagulant therapy is provided. Kits for performing the method of the invention are also provided.
L'invention concerne des procédés d'évaluation rapide des propriétés coagulantes globales d'un échantillon sanguin d'un patient, qui consistent à mesurer et à comparer le temps de coagulation avec et sans inhibiteur ajouté d'un procoagulant ou d'un anticoagulant. Lorsque l'échantillon est constitué de sang entier, le temps de coagulation résultant représente l'activité coagulante globale du plasma et des composants cellulaires du sang, laquelle est représentative d'une pathologie existante ou imminente découlant d'une coagulabilité anormale. L'invention porte également sur un procédé de mesure du risque chez un patient d'événement thrombotique, par la détermination des taux courants au plan fonctionnel de procoagulant(s) ou d'anticoagulant(s) dans le sans entier. Par ailleurs, une méthode de mesure de l'efficacité d'une thérapie anticoagulante est décrite ainsi que des kits pour la mise en oeuvre de la méthode de l'invention.
Mackman Nigel
Mcdonnell John J.
Coagulation Diagnostics Inc.
Mbm & Co.
The Scripps Research Institute
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