G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/58 (2006.01) A61K 49/00 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2576820
The Applicants have established a simple, rapid assay of measuring the dynamics of self-assembling systems of biological molecules, based on stable isotope labeling technology that can be used in intact animals including humans. Examples of self-assembling systems of biological molecules include microtubule polymers, actin filaments, amyloid-beta plaques or fibrils, prion plaques or fibrils, fibrin aggregates, tau filaments (e.g., neurofibrillary tangles), .alpha.-synuclein filaments, and mutant hemoglobin aggregates. The method reveals constitutive differences in the dynamics of assembly and disassembly between tissues and is sensitive to the action of compounds that stabilize these dynamics.
Procédé simple et rapide permettant de mesurer les dynamiques de systèmes auto-asembleurs de molécules biologiques à partir d'une technologie de marquage isotopique convenant pour des animaux intacts, y compris humains. Les systèmes auto-assembleurs de molécules biologiques recouvrent par exemple les polymères à microtubules, les filaments d'actine, les plaques ou les fibrilles bêta-amyloïdes, les plaques ou fibrilles de prions, les agrégats de fibrine, les filaments tau (tels que les enchevêtrements neurofibrillaires), les filaments d'.alpha.-nucléine et les agrégats d'hémoglobine mutante. Ce procédé fait apparaître des différences dans la dynamique d'assemblage et de désassemblage entre tissus et reflète l'action de composés qui stabilisent ces dynamiques.
Fanara Patrizia A.
Hellerstein Marc K.
Kinemed Inc.
Smart & Biggar
LandOfFree
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