Method for measuring nitrosyl (feii)-hemoglobin

G - Physics – 01 – N

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G01N 33/72 (2006.01) A61K 31/00 (2006.01) A61K 31/04 (2006.01) A61K 31/095 (2006.01) A61K 31/195 (2006.01) A61K 47/48 (2006.01) G01N 21/63 (2006.01) G01N 21/76 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2232050

Nitrosyl (FeII)-hemoglobin can be detected in biological samples, using a method which involves injection of samples into a photolysis cell, prior to detection of chemiluminescence generated by the reaction between nitric oxide and ozone. This method is useful for monitoring the levels of nitric oxide bioactivity in both normal physiological states, and disease states, such as septic shock, atherosclerosis, thrombosis, hyperhomocysteinemia, pulmonary hypertension, malignancy, infections and central nervous system disorders.

La nitrosyle (FeII)-hémoglobine peut être détectée dans des échantillons biologiques à l'aide d'un procédé qui consiste à injecter des échantillons dans une cellule de photolyse avant de détecter la chimiluminescence générée par la réaction entre l'oxyde nitrique et l'ozone. Ce procédé est utilisé pour contrôler les niveaux de bioactivité de l'oxyde nitrique à la fois dans des états physiologiques normaux et dans des états pathologiques tels que le choc septique, l'athérosclérose, la thrombose, l'hyperhomocystéinémie, l'hypertension pulmonaire, les tumeurs malignes, les infections et les troubles du système nerveux central.

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