G - Physics – 01 – N
Patent
G - Physics
01
N
167/41
G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/544 (2006.01) G01N 33/577 (2006.01) G01N 33/74 (2006.01) G01N 33/78 (2006.01)
Patent
CA 1340536
A one-step assay for the free portion of a ligand in a biological sample involves incubating a mixture of the sample with a labelled antibody for the ligand and a ligand analogue which competes with the ligand for binding to the antibody. The assay is characterized by using a monoclonal antibody and by choosing a ligand analogue which has a lower affinity for the antibody than does the ligand. An insolubilised ligand analogue preferably has a binding affinity for the antibody from 0.01% to 10% of that of the ligand. Ligand/ligand analogue pairs exemplified are T4/T3 (Thyroxine/Tri- iodothyronine); Testosterone/etiocholanol; and T3/T2.
587598
Christofides Nicos Demetriou
Midgley John Edward Maurice
Sheehan Christopher Peter
Amerlite Diagnostics Limited
Amersham International Plc
Kirby Eades Gale Baker
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