G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 13/02 (2006.01) G01N 5/04 (2006.01)
Patent
CA 2433757
The present invention is directed to a method for determining the surface activity properties of an amphiphilic substance, such as a drug, the method including a step wherein the surface tension of an aqueous solution of the said substance is measured at its air-water interface at a plurality of concentrations of said substance and determining the relationship between the surface tension and the concentration of the substance, and using the relationship so determined to predict the surface activity properties of the substance, according to which method, to the aqueous solution, a water soluble substance, which increases the surface tension of the aqueous solution is added in an amount to provide a concentration of 0.3 M up to the saturation concentration of the said substance in said solution.
L'invention concerne un procédé permettant de déterminer les propriétés d'activité superficielle d'une substance amphiphile, telle qu'un médicament. Le procédé comprend une étape dans laquelle la tension superficielle d'une solution aqueuse de ladite substance est mesurée au niveau de son interface air-eau à différentes concentrations, le procédé consistant ensuite à déterminer la relation entre la tension superficielle et la concentration de la substance, et à utiliser la relation ainsi déterminée pour prédire les propriétés d'activité superficielle de la substance. Une substance hydrosoluble qui augmente le tension superficielle de la solution aqueuse est ajoutée à cette dernière en quantités produisant une concentration de 0,3 M jusqu'à la concentration de saturation de ladite substance dans ladite solution.
Kinnunen Paavo
Soderlund Tim
Kibron Inc. Oy
Mccarthy Tetrault Llp
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