Method for modifying a protein structure

Details Method for modifying a protein structure Method for modifying a protein structure

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) C07K 1/107 (2006.01) G01N 33/68 (2006.01) G11C 13/02 (2006.01)

Patent

CA 2425689

The present invention relates to stabilisation of proteins. A theoretical basis for new protein engineering strategies is presented, based on defining rules for strong hydrogen bonds in proteins. In the present invnetion pairs of carboxylic acid side chains are used to stabilise proteins, or to form pH- dependent molecular switches.

La présente invention concerne la stabilisation de protéines, plus particulièrement une base théorique pour de nouvelles stratégies d'ingénierie des protéines, fondée sur la définition de règles pour de fortes liaisons hydrogène dans les protéines. Selon la présente invention, des paires de chaînes latérales d'acide carboxylique sont utilisées pour stabiliser des protéines ou pour former des séquences activatrices dépendant du pH.

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