A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2231433
The invention is based upon the newly recognized ability of .beta. chemokines to inhibit cell apoptosis. In particular, apoptosis of T cells is described. The known .beta. chemokines I-309 and TCA-3 are examples of the .beta. chemokines which inhibit apoptosis. One aspect of the invention is the use of these molecules to inhibit apoptosis. A second aspect of the invention is the use of .beta. chemokine inhibitors or antagonists to provoke apoptosis.
L'invention se rapporte à la faculté, jusque-là inconnue, des .beta. chémokines d'inhiber l'apoptose. On décrit en particulier l'apoptose des lymphocytes T. Les chémokines .beta. I-309 et TCA-3 sont des exemples de chémokines inhibant l'apoptose. Au fin de la présente invention, un premier aspect consiste à utiliser ces molécules pour inhiber l'apoptose et un second aspect consiste à utiliser lesdites chémokines .beta. comme inhibiteurs ou comme antagonistes en vue de déclencher l'apoptose.
Houssiau Frederic
Proost Paul
Renauld Jean-Christophe
Van Damme Jo
Ludwig Institute For Cancer Research
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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