Method for modulating macrophage activation

Details Method for modulating macrophage activation Method for modulating macrophage activation

A - Human Necessities

61

K

A61K 31/185 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2320224

Anionic compounds, including sulfonates, are capable of blocking A.beta.- induced macrophage activation (or macrophage activation induced by other amyloidogenic proteins or peptides). Such compounds can inhibit the inflammatory process, e.g., in the brain of a subject suffering from a disease characterized by A.beta. deposition, such as Alzheimer's disease.

La présente invention concerne des composés anioniques, dont des sulfonates, capables de bloquer l'activation des macrophages induite par la protéine A beta (ou une activation des macrophages induite par d'autres protéines ou peptides amyloïdogéniques). Ces composés peuvent inhiber le processus inflammatoire, par exemple dans le cerveau d'un sujet souffrant d'une maladie caractérisée par un dépôt A beta telle la maladie d'Alzheimer.

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