Method for modulating processes mediated by farnesoid...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 31/045 (2006.01) A61K 31/08 (2006.01) A61K 31/19 (2006.01) A61K 31/22 (2006.01) C07K 14/705 (2006.01) C12Q 1/66 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2210190

Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified that is transcriptionally activated by farnesol and related molecules. This novel signaling pathway can be modulated by the use of key metabolic intermediates (or analogs and/or derivatives thereof) as transcriptional regulatory signals.

Le farnésyl-pyrophosphate, qui est la forme métaboliquement active du farnésol, est un précurseur clé de la synthèse du cholestérol, des caroténoïdes, des hormones stéroïdes, des acides biliaires et d'autres molécules intervenant dans la croissance cellulaire et le métabolisme. On a identifié un récepteur nucléaire qui est activé au moment de la transcription par le farnésol et des molécules apparentées. Cette nouvelle voie de signalisation peut être modulée par l'utilisation d'intermédiaires métaboliques (ou d'analogues et/ou de dérivés de ce dernier) comme signaux de régulation de la transcription.

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