C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 38/02 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/665 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2117599
This invention provides a novel method for decreasing proopiomelanocortin (POMC) synthesis in a mammal such as a human comprising administering to the mammal an effective amount of a molecule capable of binding to a mammalian POMC mRNA stem loop structure. The invention further provides a method for increasing POMC synthesis in a mammal comprising administering to the mammal an effective amount of an mRNA POMC stem-loop structure. A method of identifying compounds capable of modulating POMC synthesis in a mammal is also provided. The method comprises identifying compounds which bind to a proopiomelanocortin mRNA stem-loop structure.
Eberwine James H.
Spencer Corinne
Borden Ladner Gervais Llp
The Trustees Of The University Of Pennsylvania
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