Method for modulating the binding activity of a novel icam-3...

Details Method for modulating the binding activity of a novel icam-3... Method for modulating the binding activity of a novel icam-3...

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2431990

The invention relates to the use of a compound that binds to a C-type lectin on the surface of a sinusoid endothelial layer, in the preparation of a composition for modulating, in particular reducing, the immune response in animal, in particular a human or another mammal. The sinusoid endothelial layer may be either constituted by liver sinusoid endothelial cells (LSEC) or by the lymph node sinusoidal zone.

La présente invention concerne l'utilisation d'un composé qui se lie à une lectine de type C située sur la surface d'une couche endothéliale sinusoïdale, dans la préparation d'une composition servant à moduler, et plus particulièrement, à réduire la réponse immunitaire chez l'animal, notamment chez l'homme ou un autre mammifère. La couche endothéliale sinusoïdale peut être constituée soit de cellules endothéliales sinusoïdales du foie soit par la zone sinusoïdale des ganglions lymphatiques.

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