C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12P 21/06 (2006.01) C12Q 1/02 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2452849
This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced by adding folding promoting agents and/or co-expression of the periplasmic chaperone (Skp). In this respect, the invention offers a technology to improve the yield of functionally expressed recombinant proteins.
L'invention concerne une nouvelle méthode destinée à améliorer l'expression des protéines fonctionnelles. Cette méthode consiste à surveiller le processus de repliement par mesure continue et, si nécessaire, à influer sur le repliement des protéines par addition d'agents favorisant le repliement et/ou par co-expression de la chaperone périplasmique Skp. Par conséquent, l'invention offre une technique permettant d'améliorer le rendement des protéines recombinantes exprimées de manière fonctionnelle.
Horn Uwe
Riesenberg Dieter
Strittmatter Wolfgang
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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