Method for monitoring in peptide synthesis

Details Method for monitoring in peptide synthesis Method for monitoring in peptide synthesis

C - Chemistry, Metallurgy

07

K

530/1.02

C07K 1/02 (2006.01)

Patent

CA 2033280

ABSTRACT A method for monitoring the reaction between an activated carboxylic acid derivative and an amine, such as the formation of a peptide bond in peptide synthesis, whereby an inert anionic dye component and an inert cationic component are included in the reaction system, in small relative amounts compared to the carboxylic acid derivative. The distribution of the dye component to said cationic component, when separated from the amine component, is monitored and at a given maximun value indicates a substantially quantitative reaction.

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