Method for non-invasive blood analyte measurement with...

A - Human Necessities – 61 – B

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A61B 5/1455 (2006.01) A61B 5/00 (2006.01)

Patent

CA 2347040

This invention is a method for non-invasive measuring the concentration of an analyte, particularly blood analyte in blood. The method utilizes spectrographic techniques (30) in conjunction with an improved optical interface between a sensor probe (11), and a skin surface (12) or tissue surface of the body containing the blood to be analyzed. An index matching medium (22) is disclosed to improve the interface between the sensor probe, and the skin surface during spectrographic analysis. In a preferred embodiment, the blood analyte concentration in blood is quantified utilizing a partial squares analysis relative to a model incorporating analysis of plural known blood samples.

Cette invention est une méthode de mesure non sanglante de la concentration d'un analyte, en particulier un analyte du sang, dans le sang. La méthode utilise des techniques spectrographiques (30) conjointement à une interface optique améliorée entre une sonde détecteur (11) et une surface cutanée (12) ou une surface tissulaire du corps contenant le sang à analyser. Un milieu (22) d'appariement d'indices est décrit pour améliorer l'interface entre la sonde détecteur et la surface cutanée pendant l'analyse spectrographique. Dans un mode de réalisation préféré, la concentration d'analyte sanguin dans le sang est quantifiée à l'aide d'une analyse partielle des carrés par rapport à un modèle incorporant une analyse de plusieurs échantillons de sang connus.

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