Method for obtaining a 2-18f-fluor-2-deoxy-d-glucose...

Details Method for obtaining a 2-18f-fluor-2-deoxy-d-glucose... Method for obtaining a 2-18f-fluor-2-deoxy-d-glucose...

A - Human Necessities

61

K

A61K 51/04 (2006.01) A61K 51/12 (2006.01)

Patent

CA 2483181

The invention relates to a method for improving one or more physical/chemical characteristics, like reduced radiolysis of and the ability to autoclave, a 18F-fluor-deoxy-glucose (18F-FDG)-solution, which method comprises the steps of a) provision of a 18F-fluor-deoxy-glucose (18F-FDG)-solution, and b) addition of at least one buffer based on a weak acid to the 18F-fluor-deoxy- glucose (18F-FDG)-solution. The invention also relates to a method for preparing a sterile 18F-fluor-deoxy-glucose (18F-FDG)-solution by autoclaving said 18F-fluor-deoxy-glucose (FDG)-solution.

L'invention porte sur un procédé permettant d'améliorer au moins une caractéristique physique/chimique, telle que la radiolyse réduite de la solution 18F-fluor-deoxy-glucose (18F-FDG) et la capacité d'autoclaver cette dernière. Ce procédé consiste : a) à fournir une solution 18F-fluor-deoxy-glucose (18F-FDG), et b) à ajouter au moins un tampon à base d'un acide faible dans la solution 18F-fluor-deoxy-glucose (18F-FDG). Cette invention concerne aussi un procédé de préparation d'une solution stérile 18F-fluor-deoxy-glucose (18F-FDG) par autoclave de la solution 18F-fluor-deoxy-glucose (FDG).

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