Method for obtaining a singular cell model capable of...

Details Method for obtaining a singular cell model capable of... Method for obtaining a singular cell model capable of...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C12N 15/53 (2006.01) C12N 15/54 (2006.01) C12N 15/55 (2006.01)

Patent

CA 2553995

The method is based on the use of expression vectors coding for the sense and anti-sense mRNA of the Phase I and Phase II drug biotransformation enzymes showing a greatest variability in humans for transforming cells expressing reductase activity. Such vectors can modulate (increase or decrease) the individualised expression of an enzyme without affecting the other enzymes. This singular cell model can reproduce in vitro the metabolic idiosyncrasy of humans. It is applicable in the study of development of new drugs, specifically in the study of metabolism, potential idiosyncratic hepatotoxicity, medicament interactions, etc., of new drugs.

Selon l'invention, le procédé s'appuie sur l'utilisation de vecteurs d'expression codant pour les ARNm sens et antisens des enzymes de biotransformation de médicaments des phase I et phase II, illustrant une très grande variabilité chez les humains pour transformer des cellules exprimant une activité réductase. Ces vecteurs peuvent moduler (en augmentant ou en réduisant) l'expression individualisée d'une enzyme sans affecter les autres enzymes. Le modèle cellulaire singulier peut reproduire in vitro l'idiosyncrasie métabolique chez les humains. On peut l'appliquer dans l'étude du développement de nouveaux médicaments, plus précisément dans l'étude du métabolisme, de l'hépatotoxicité idiosyncratique, des interactions médicamenteuses, etc., de ces nouveaux médicaments.

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