A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01)
Patent
CA 2744510
The present invention relates to a method of ultra- and dialfiltrating an antibody solution containing at least one solute in addition to the antibody, which comprises diafiltrating the antibody solution with a solvent and bringing said mixture into contact with a semi-permeable membrane so as to allow the at least one solute present in the antibody solution and having a molecular weight lower than the molecular weight cut-off of the membrane to pass through the membrane, whilst retaining the antibody so that a modified antibody solution is obtained that only contains the antibody and the solvent.
La présente invention porte sur un procédé d'ultrafiltration et de dialfiltration d'une solution d'anticorps contenant au moins un soluté en plus de l'anticorps, lequel procédé comprend la dialfiltration de la solution d'anticorps avec un solvant et la mise en contact dudit mélange avec une membrane semi-perméable de façon à permettre à au moins un soluté présent dans la solution d'anticorps et ayant une masse moléculaire inférieure à la limite de masse moléculaire de la membrane de passer à travers la membrane, l'anticorps étant retenu de façon à obtenir une solution d'anticorps modifiée qui contient uniquement l'anticorps et le solvant.
Mahler Hanns-Christian
Mueller Robert
Borden Ladner Gervais Llp
F.hoffmann-La Roche Ag
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