Method for obtaining antigen-specific tr1 regulatory...

Details Method for obtaining antigen-specific tr1 regulatory... Method for obtaining antigen-specific tr1 regulatory...

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2446981

The invention relates to a method for preparing antigen-specific Tr1 regulatory lymphocytes. The inventive method involves the use of artificial antigen-presenting cells, expressing a molecule from the HLA class II system and a human LFA-3 molecule and expressing none of the B7-1, B7-2, B7-H1, CD40, CD23 or ICAM-1 costimulation molecules.

L'invention concerne un procédé de préparation de lymphocytes régulateurs Tr1 spécifiques d'antigène, utilisant des cellules présentatrices de l'antigène artificielles, exprimant une molécule du système HLA de classe II et une molécule de LFA-3 humain et n'exprimant aucune des molécules de co-stimulation B7-1, B7-2, B7-H1, CD40, CD23 ou ICAM-1.

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