Method for obtaining micro- and nano-disperse systems

Details Method for obtaining micro- and nano-disperse systems Method for obtaining micro- and nano-disperse systems

B - Operations, Transporting

01

J

B01J 13/00 (2006.01) A61H 9/00 (2006.01)

Patent

CA 2566960

The invention relates to a method for obtaining micro- and nanodisperse systems. In particular, it relates to a method that allows said systems, such as liposomes, emulsions and suspensions, to be obtained with a size of less than 50mm, and preferably less than 1mm, and with improved stability properties over time, which includes the stages of a) Dissolving or suspending a compound C in a fluid A, to obtain a mixture A, in the form of a solution or dispersion; b) Thermostatising said mixture A to a temperature of between - 50~C and 200~C; c) Adding a fluid B to mixture A until a pressure P is obtained; and it is characterised in that in said stage (c) formation of the solution AB occurs and because it includes, d) Reducing the pressure of solution AB to a pressure lower than or equal to 100 bars, and then e) Adding a fluid E, in which fluid A is miscible and in which compound C is partially or totally insoluble at atmospheric pressure, with said fluid E acting as a crystallisation interruption agent.

La présente invention a trait à un procédé pour l'obtention de systèmes de microdispersion et de nanodispersion. En particulier, l'invention a trait à un procédé qui permet l'obtention desdits systèmes, tels que des liposomes, émulsions et suspensions avec une taille inférieure à 50 µm, et de préférence inférieur à 1 µm, et avec des propriétés de stabilité améliorées dans le temps, comprenant les étapes suivantes: a) la dissolution ou la suspension d'un composé C dans un fluide A, en vue d'obtenir un mélange A, sous la forme d'une solution ou dispersion; b) la thermostatisation dudit mélange A à une température comprise entre -50 °C et 200 °C; c) l'ajout d'un fluide B au mélange A jusqu'à l'obtention d'une pression P. Le procédé est caractérisé en ce qu'au cours de l'étape (c), la formation de la solution AB se produit et en ce qu'il comprend d) la réduction de la pression de la solution AB à une pression inférieure ou égale à 100 bars, et ensuite e) l'ajout d'un fluide E, dans lequel le fluide A est miscible et dans lequel le composé C est partiellement ou entièrement insoluble à la pression atmosphérique, ledit fluide E agissant comme un agent d'interruption de cristallisation.

Affiliated with

Also associated with

Rating

Method for obtaining micro- and nano-disperse systems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for obtaining micro- and nano-disperse systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for obtaining micro- and nano-disperse systems will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1596048